IgG Galactosylation status combined with MYOM2-rs2294066 precisely predicts anti-TNF response in ankylosing spondylitis

IgG Galactosylation status combined with MYOM2-rs2294066 precisely predicts anti-TNF response in ankylosing spondylitis

Abstract Background Tumor necrosis factor (TNF) blockers have a high efficacy in treating Ankylosing Spondylitis (AS), yet up to 40% of AS patients show poor or even no response to this treatment. In this paper, we aim to build an approach to predict the response prior to clinical treatment. Methods...

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Bibliographic Details
Main Authors: Jing Liu, Qi Zhu, Jing Han, Hui Zhang, Yuan Li, Yanyun Ma, Dongyi He, Jianxin Gu, Xiaodong Zhou, John D. Reveille, Li Jin, Hejian Zou, Shifang Ren, Jiucun Wang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Medicine
Subjects:
Ankylosing spondylitis
IgG-gal ratio
MYOM2-rs2294066
TNF blocker
Drug response prediction
Online Access:http://link.springer.com/article/10.1186/s10020-019-0093-2

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http://link.springer.com/article/10.1186/s10020-019-0093-2

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