Cross-Reactivity of Virus-Specific CD8+ T Cells Against Allogeneic HLA-C: Possible Implications for Pregnancy Outcome

Cross-Reactivity of Virus-Specific CD8+ T Cells Against Allogeneic HLA-C: Possible Implications for Pregnancy Outcome

Heterologous immunity of virus-specific T cells poses a potential barrier to transplantation tolerance. Cross-reactivity to HLA-A and -B molecules has broadly been described, whereas responses to allo-HLA-C have remained ill defined. In contrast to the transplant setting, HLA-C is the only polymorph...

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Bibliographic Details
Main Authors: Anita van der Zwan, Ellen M. W. van der Meer-Prins, Paula P. M. C. van Miert, Heleen van den Heuvel, Jacqueline D. H. Anholts, Dave L. Roelen, Frans H. J. Claas, Sebastiaan Heidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
heterologous immunity
virus-specific T cells
allogeneic HLA
HLA-C
pregnancy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02880/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02880/full

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