Targeting NRF2-Governed Glutathione Synthesis for <i>SDHB</i>-Mutated Pheochromocytoma and Paraganglioma

Targeting NRF2-Governed Glutathione Synthesis for <i>SDHB</i>-Mutated Pheochromocytoma and Paraganglioma

Succinate dehydrogenase subunit B (SDHB) deficiency frequently occurs in cluster I pheochromocytomas and paragangliomas (PCPGs). <i>SDHB</i>-mutated PCPGs are characterized by alterations in the electron transport chain, metabolic reprogramming of the tricarboxylic cycle, and elevated le...

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Bibliographic Details
Main Authors: Yang Liu, Ying Pang, Veronika Caisova, Jianyi Ding, Di Yu, Yiqiang Zhou, Thanh-Truc Huynh, Hans Ghayee, Karel Pacak, Chunzhang Yang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
nrf2
glutathione metabolism
sdhb mutation
pheochromocytoma
paraganglioma
Online Access:https://www.mdpi.com/2072-6694/12/2/280

Internet

https://www.mdpi.com/2072-6694/12/2/280

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