Deleterious Mutations in DNA Repair Gene FANCC Exist in BRCA1/2-Negative Chinese Familial Breast and/or Ovarian Cancer Patients

Deleterious Mutations in DNA Repair Gene FANCC Exist in BRCA1/2-Negative Chinese Familial Breast and/or Ovarian Cancer Patients

Introduction:FANCC is reported as a novel susceptibility gene for breast cancer, however, its mutation remains unclear in Chinese population. We aimed to identify the germline mutations of FANCC in high-risk breast cancer patients in China.Methods: 255 BRCA1/2-negative Chinese familial breast and/or...

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Bibliographic Details
Main Authors: Zhi-Wen Pan, Xiao-Jia Wang, Tianhui Chen, Xiao-Wen Ding, Xiyi Jiang, Yun Gao, Wen-Ju Mo, Yuan Huang, Cai-Jin Lou, Wen-Ming Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Oncology
Subjects:
Chinese
familial breast cancer
familial ovarian cancer
FANCC
deleterious mutation
susceptibility
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00169/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00169/full

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