Resistance to dasatinib is associated with the activation of Akt in oral squamous cell carcinoma

Resistance to dasatinib is associated with the activation of Akt in oral squamous cell carcinoma

Objectives: Overexpression and aberrant activation of Src promote the development of oral squamous cell carcinoma (OSCC), thus therapies targeting Src-related kinases may afford an improvement in patient survival. However, limited clinical activity of the Src-targeted drug, dasatinib, in cancer pati...

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Main Authors: Pei San Yee, Chai Phei Gan, Nur Syafinaz Zainal, Ivy KN Chiang, Kalen R Dionne, Muhammad ZH Fadlullah, Bernard KB Lee, Kai Hung Tiong, Kein Seong Mun, Mannil T Abraham, Siti M Ismail, Zainal A Abdul Rahman, Vyomesh Patel, Sok Ching Cheong
Format: Article
Language:English
Published: SAGE Publishing 2017-07-01
Series:Translational Research in Oral Oncology
Online Access:https://doi.org/10.1177/2057178X17702920

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https://doi.org/10.1177/2057178X17702920

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