Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity

Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity

T cell cross-reactivity ensures that diverse pathogen-derived epitopes encountered during a lifetime are recognized by the available TCR repertoire. A feature of cross-reactivity where previous exposure to one microbe can alter immunity to subsequent, non-related pathogens has been mainly explored f...

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Bibliographic Details
Main Authors: Juan L Mendoza, Suzanne Fischer, Marvin H Gee, Lilian H Lam, Simon Brackenridge, Fiona M Powrie, Michael Birnbaum, Andrew J McMichael, K Christopher Garcia, Geraldine M Gillespie
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
HIV
sporosarcina newyorkensis
CD8 T cells
MHC
Online Access:https://elifesciences.org/articles/58128

Internet

https://elifesciences.org/articles/58128

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