Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections

Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections

Due to the high risk of an outbreak of pandemic influenza, the development of a broadly protective universal influenza vaccine is highly warranted. The design of such a vaccine has attracted attention and much focus has been given to nanoparticle-based influenza vaccines which can be administered in...

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Bibliographic Details
Main Authors: Valentina Bernasconi, Beatrice Bernocchi, Liang Ye, Minh Quan Lê, Ajibola Omokanye, Rodolphe Carpentier, Karin Schön, Xavier Saelens, Peter Staeheli, Didier Betbeder, Nils Lycke
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
mucosal vaccination
influenza A virus
CTA1-DD
maltodextrin nanoparticles
targeted adjuvant
nasal immunization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02060/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02060/full

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