A cross-metathesis approach to novel pantothenamide derivatives
Pantothenamides are known for their in vitro antimicrobial activity. Our group has previously reported a new stereoselective route to access derivatives modified at the geminal dimethyl moiety. This route however fails in the addition of large substituents. Here we report a new synthetic route that...
Main Authors: | Jinming Guan, Matthew Hachey, Lekha Puri, Vanessa Howieson, Kevin J. Saliba, Karine Auclair |
---|---|
Format: | Article |
Language: | English |
Published: |
Beilstein-Institut
2016-05-01
|
Series: | Beilstein Journal of Organic Chemistry |
Subjects: | |
Online Access: | https://doi.org/10.3762/bjoc.12.95 |
Similar Items
-
Down regulation of the expression of mitochondrial phosphopantetheinyl-proteins in pantothenate kinase-associated neurodegeneration: pathophysiological consequences and therapeutic perspectives
by: Mónica Álvarez-Córdoba, et al.
Published: (2021-05-01) -
Preparation of Key Intermediates for the Syntheses of Coenzyme Q<sub>10</sub> and Derivatives by Cross-Metathesis Reactions
by: Trang Nguyen, et al.
Published: (2020-01-01) -
Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents
by: Hailey S. Butman, et al.
Published: (2020-12-01) -
Characterization of prokaryotic pantothenate kinase enzymes and the development of type-specific inhibitors
by: Koekemoer, Lizbe
Published: (2011) -
Structural Studies of the Klebsiella Pneumoniae Pantothenate Kinase in Complex with Pantothenamide Substrate Analogues
by: Li, Buren
Published: (2012)