Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits
<p>Abstract</p> <p>Background</p> <p>Heat shock protein 90 (HSP90) is a molecular chaperone that is considered a new target for the treatment of cancer. Increasing data reveal an extracellular chaperoning activity for HSP90. Here we investigate the interaction of the se...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2010-07-01
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Series: | BMC Cell Biology |
Online Access: | http://www.biomedcentral.com/1471-2121/11/51 |