Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits

<p>Abstract</p> <p>Background</p> <p>Heat shock protein 90 (HSP90) is a molecular chaperone that is considered a new target for the treatment of cancer. Increasing data reveal an extracellular chaperoning activity for HSP90. Here we investigate the interaction of the se...

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Bibliographic Details
Main Authors: Patsavoudi Evangelia, El Hamidieh Avraam, Stellas Dimitris
Format: Article
Language:English
Published: BMC 2010-07-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/11/51