Smooth Muscle Cell Alignment and Phenotype Control by Melt Spun Polycaprolactone Fibers for Seeding of Tissue Engineered Blood Vessels

A method has been developed to induce and retain a contractile phenotype for vascular smooth muscle cells, as the first step towards the development of a biomimetic blood vessel construct with minimal compliance mismatch. Melt spun PCL fibers were deposited on a mandrel to form aligned fibers of 10 ...

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Bibliographic Details
Main Authors: Animesh Agrawal, Bae Hoon Lee, Scott A. Irvine, Jia An, Ramya Bhuthalingam, Vaishali Singh, Kok Yao Low, Chee Kai Chua, Subbu S. Venkatraman
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:International Journal of Biomaterials
Online Access:http://dx.doi.org/10.1155/2015/434876