The angiotensin II receptor-neprilysin inhibitor LCZ696 attenuates the progression of proteinuria in type 2 diabetic rats

We examined the effects of the angiotensin receptor-neprilysin inhibitor LCZ696 on overt proteinuria and renal injury in type 2 diabetic Otsuka-Long- Evans-Tokushima-Fatty (OLETF) rats. Aged OLETF rats were also treated with either valsartan or valsartan plus hydralazine for comparison. LCZ696 cause...

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Bibliographic Details
Main Authors: Asadur Rahman, Shamshad J. Sherajee, Kazi Rafiq, Hideki Kobara, Tsutomu Masaki, Daisuke Nakano, Takashi Morikawa, Yoshio Konishi, Masahito Imanishi, Akira Nishiyama
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319357391