Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors.

Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors.

Research on the obligate intracellular bacterium Chlamydia trachomatis demands culture in cell-lines, but the adaptive process behind the in vivo to in vitro transition is not understood. We assessed the genomic and transcriptomic dynamics underlying C. trachomatis in vitro adaptation of strains rep...

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Bibliographic Details
Main Authors: Vítor Borges, Miguel Pinheiro, Minia Antelo, Daniel A Sampaio, Luís Vieira, Rita Ferreira, Alexandra Nunes, Filipe Almeida, Luís J Mota, Maria J Borrego, João P Gomes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0133420

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https://doi.org/10.1371/journal.pone.0133420

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