A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement

A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement

The global impact of somatic structural variants (SSVs) on gene expression in childhood cancers is unclear. Here, the authors analyse cancer genome and RNA sequencing data of 854 pediatric brain tumours and report a landscape of genes deregulated by SSVs.

Bibliographic Details
Main Authors: Yiqun Zhang, Fengju Chen, Lawrence A. Donehower, Michael E. Scheurer, Chad J. Creighton
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21081-y
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spelling doaj-db8ca0e9586749df99643f4d66cc5fc92021-02-14T12:12:28ZengNature Publishing GroupNature Communications2041-17232021-02-0112111710.1038/s41467-021-21081-yA pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangementYiqun Zhang0Fengju Chen1Lawrence A. Donehower2Michael E. Scheurer3Chad J. Creighton4Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of MedicineDan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of MedicineDepartment of Molecular Virology and Microbiology, Baylor College of MedicineDan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of MedicineDan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of MedicineThe global impact of somatic structural variants (SSVs) on gene expression in childhood cancers is unclear. Here, the authors analyse cancer genome and RNA sequencing data of 854 pediatric brain tumours and report a landscape of genes deregulated by SSVs.https://doi.org/10.1038/s41467-021-21081-y
collection DOAJ
language English
format Article
sources DOAJ
author Yiqun Zhang
Fengju Chen
Lawrence A. Donehower
Michael E. Scheurer
Chad J. Creighton
spellingShingle Yiqun Zhang
Fengju Chen
Lawrence A. Donehower
Michael E. Scheurer
Chad J. Creighton
A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
Nature Communications
author_facet Yiqun Zhang
Fengju Chen
Lawrence A. Donehower
Michael E. Scheurer
Chad J. Creighton
author_sort Yiqun Zhang
title A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
title_short A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
title_full A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
title_fullStr A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
title_full_unstemmed A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
title_sort pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description The global impact of somatic structural variants (SSVs) on gene expression in childhood cancers is unclear. Here, the authors analyse cancer genome and RNA sequencing data of 854 pediatric brain tumours and report a landscape of genes deregulated by SSVs.
url https://doi.org/10.1038/s41467-021-21081-y
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AT lawrenceadonehower apediatricbraintumoratlasofgenesderegulatedbysomaticgenomicrearrangement
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