Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer

Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer

Abstract Background Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression. Disseminated tumor cells encounter major changes in nutrient supplies and oxidative stresses compared to the primar...

Full description

Bibliographic Details
Main Authors: Aparna Shinde, Tomasz Wilmanski, Hao Chen, Dorothy Teegarden, Michael K. Wendt
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Metastasis
Pyruvate carboxylase
Metabolism
Glycolysis
Hypoxia
Online Access:http://link.springer.com/article/10.1186/s13058-018-1008-9

Internet

http://link.springer.com/article/10.1186/s13058-018-1008-9

Similar Items