A prospective study of the adaptive changes in the gut microbiome during standard-of-care chemoradiotherapy for gynecologic cancers.

<h4>Background</h4>A diverse and abundant gut microbiome can improve cancer patients' treatment response; however, the effect of pelvic chemoradiotherapy (CRT) on gut diversity and composition is unclear. The purpose of this prospective study was to identify changes in the diversity...

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Main Authors: Molly B El Alam, Travis T Sims, Ramez Kouzy, Greyson W G Biegert, Joseph A B I Jaoude, Tatiana V Karpinets, Kyoko Yoshida-Court, Xiaogang Wu, Andrea Y Delgado-Medrano, Melissa P Mezzari, Nadim J Ajami, Travis Solley, Mustapha Ahmed-Kaddar, Lilie L Lin, Lois Ramondetta, Amir Jazaeri, Anuja Jhingran, Patricia J Eifel, Kathleen M Schmeler, Jennifer Wargo, Ann H Klopp, Lauren E Colbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0247905