A novel in vitro human macrophage model to study the persistence of Mycobacterium tuberculosis using Vitamin D and retinoic acid activated THP-1 macrophages

A novel in vitro human macrophage model to study the persistence of Mycobacterium tuberculosis using Vitamin D and retinoic acid activated THP-1 macrophages

Mycobacterium tuberculosis (Mtb) replicates within the human macrophages and we investigated the activating effects of retinoic acid (RA) and vitamin D3 (VD) on macrophages in relation to the viability of Mtb. A combination of these vitamins (RAVD) enhanced the receptors on THP-1 macrophage (Mannose...

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Bibliographic Details
Main Authors: Jaymie eEstrella, Celestine eKan-Sutton, King eGong, Tony N Eissa, Malini eRajagopalan, Dorothy eLewis, Robert eHunter, Chinnaswamy eJagannath
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Latent Tuberculosis
Mycobacterium
Tuberculosis
DC-SIGN
Mannose receptor
THP-1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00067/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00067/full

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