Attenuated levels of hippocampal connexin 43 and its phosphorylation correlate with antidepressant- and anxiolytic-like activities in mice

Attenuated levels of hippocampal connexin 43 and its phosphorylation correlate with antidepressant- and anxiolytic-like activities in mice

Clinical and preclinical studies have implicated glial anomalies in major depression. Conversely, evidence suggests that the activity of antidepressant drugs is based, at least in part, on their ability to stimulate density and/or activity of astrocytes, a major glial cell population. Despite this r...

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Bibliographic Details
Main Authors: Gaël eQuesseveur, Benjamin ePortal, Jean-Arnaud eBasile, Pascal eEzan, Alexia eMathou, Hélène eHalley, Corinne eLeloup, Xavier eFioramonti, Nicole eDéglon, Christian eGiaume, Claire eRampon, Bruno Pierre Guiard
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Anxiety
Astrocytes
Behavior
Connexin 43
Depression
Hippocampus
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00490/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00490/full

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