Clinical application of the AUC-guided dosage adjustment of docetaxel-based chemotherapy for patients with solid tumours: a single centre, prospective and randomised control study

Clinical application of the AUC-guided dosage adjustment of docetaxel-based chemotherapy for patients with solid tumours: a single centre, prospective and randomised control study

Abstract Background Docetaxel (DTX) is a widely used anti-tumour drug, and its dosage is solely determined by body surface area (BSA). Adverse events, such as neutropenia or unsatisfied efficacy, likely occur because of differences in the pharmacokinetics (PK) and pharmacodynamics of patients. Thus,...

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Bibliographic Details
Main Authors: Ning Sun, Bo Shen, Jiali Zhu, Xiaomei Zhang, Huayun Zhu, Geyu Liang, Deliang Yang, Jianwei Lu, Yan Zhang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Translational Medicine
Subjects:
Docetaxel
Body surface area
Pharmacokinetics
Dosage
Online Access:http://link.springer.com/article/10.1186/s12967-020-02394-w

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http://link.springer.com/article/10.1186/s12967-020-02394-w

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