Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects

Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects

Abstract Background Neural tube defects (NTDs) are severe, common birth defects that result from failure of normal neural tube closure during early embryogenesis. Accumulating strong evidence indicates that genetic factors contribute to NTDs etiology, among them, HOX genes play a key role in neural...

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Bibliographic Details
Main Authors: Juan Yu, Lei Wang, Pei Pei, Xue Li, Jianxin Wu, Zhiyong Qiu, Juan Zhang, Ruifang Ao, Shan Wang, Ting Zhang, Jun Xie
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Epigenetics & Chromatin
Subjects:
Neural tube defects
Retinoic acid
Hox genes
H3K27me3
UTX
SUZ12
Online Access:https://doi.org/10.1186/s13072-019-0318-1

Internet

https://doi.org/10.1186/s13072-019-0318-1

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