Systemic T Cell Exhaustion Dynamics Is Linked to Early High Mobility Group Box Protein 1 (HMGB1) Driven Hyper-Inflammation in a Polytrauma Rat Model

Systemic T Cell Exhaustion Dynamics Is Linked to Early High Mobility Group Box Protein 1 (HMGB1) Driven Hyper-Inflammation in a Polytrauma Rat Model

We previously reported an early surge in high mobility group box protein 1 (HMGB1) levels in a polytrauma (PT) rat model. This study investigates the association of HMGB1 levels in mediating PT associated dysregulated immune responses and its influence on the cellular levels of receptor for advanced...

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Bibliographic Details
Main Authors: Preeti J. Muire, Martin G. Schwacha, Joseph C. Wenke
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
DAMPs
hyper-inflammation
extremity trauma
lymphopenia
RAGE
TLR4
Online Access:https://www.mdpi.com/2073-4409/10/7/1646

Internet

https://www.mdpi.com/2073-4409/10/7/1646

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