New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity

New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity

<p>Abstract</p> <p>Background</p> <p>Thromboxane A<sub>2</sub> is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly formed in blood platelets upon activation and plays an important role in aggregation....

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Bibliographic Details
Main Authors: Hirz Taghreed, Khalaf Ali, El-Hachem Nehme, Mrad May F, Abdallah Hassan, Créminon Christophe, Grée René, Merhi Raghida Abou, Habib Aïda, Hachem Ali, Hamade Eva
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Chemistry Central Journal
Subjects:
Cyclooxygenase-1
Anti-thrombotic
Inhibitors
Polyunsaturated fatty acid
Thrombosis
Online Access:http://journal.chemistrycentral.com/content/6/1/152

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http://journal.chemistrycentral.com/content/6/1/152

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