Development of molecular and pharmacological switches for chimeric antigen receptor T cells

Abstract The use of chimeric antigen receptor (CAR) T cell technology as a therapeutic strategy for the treatment blood-born human cancers has delivered outstanding clinical efficacy. However, this treatment modality can also be associated with serious adverse events in the form of cytokine release...

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Bibliographic Details
Main Authors: Bill X. Wu, No-Joon Song, Brian P. Riesenberg, Zihai Li
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Experimental Hematology & Oncology
Online Access:http://link.springer.com/article/10.1186/s40164-019-0151-z