Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing

Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing

Abstract Background 5′ methylation of cytosines in DNA molecules is an important epigenetic mark in eukaryotes. Bisulfite sequencing is the gold standard of DNA methylation detection, and whole-genome bisulfite sequencing (WGBS) has been widely used to detect methylation at single-nucleotide resolut...

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Bibliographic Details
Main Authors: Suhua Feng, Zhenhui Zhong, Ming Wang, Steven E. Jacobsen
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
Bisulfite sequencing
WGBS
EM-seq
TET
APOBEC
Online Access:http://link.springer.com/article/10.1186/s13072-020-00361-9

Internet

http://link.springer.com/article/10.1186/s13072-020-00361-9

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