Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection

Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection

Progress in our understanding of MR1-restricted mucosa-associated invariant T (MAIT) cells has raised interest in harnessing these cells for immunotherapy. The innate-like response characteristics, abundance in the blood, donor-unrestricted nature, and tropism for tissues make MAIT cells suitable ca...

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Bibliographic Details
Main Authors: Tiphaine Parrot, Katie Healy, Caroline Boulouis, Michał J. Sobkowiak, Edwin Leeansyah, Soo Aleman, Antonio Bertoletti, Margaret Sällberg Chen, Johan K. Sandberg
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-03-01
Series:JCI Insight
Subjects:
Immunology
Online Access:https://doi.org/10.1172/jci.insight.140074

Internet

https://doi.org/10.1172/jci.insight.140074

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