Frequency of Heterozygous Parkin (PRKN) Variants and Penetrance of Parkinson's Disease Risk Markers in the Population-Based CHRIS Cohort

Frequency of Heterozygous Parkin (PRKN) Variants and Penetrance of Parkinson's Disease Risk Markers in the Population-Based CHRIS Cohort

Mutations in the Parkin (PRKN) gene are the most frequent cause of autosomal recessive early-onset Parkinson's disease (PD). Heterozygous PRKN mutation carriers might also be at increased risk for developing clinical symptoms of PD. Given the high frequency of heterozygous mutations in the gene...

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Bibliographic Details
Main Authors: Maria Paulina Castelo Rueda, Athina Raftopoulou, Martin Gögele, Max Borsche, David Emmert, Christian Fuchsberger, Essi M. Hantikainen, Vladimir Vukovic, Christine Klein, Peter P. Pramstaller, Irene Pichler, Andrew A. Hicks
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Neurology
Subjects:
Parkin
heterozygote mutation
Parkinson's disease
risk markers
penetrance
population
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.706145/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.706145/full

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