Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery

Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery

Bacterial protein synthesis is an essential, conserved, and environmentally responsive process. Yet, many of its components and dependencies remain unidentified. To address this gap, we used quantitative synthetic genetic arrays to map functional relationships among >48,000 gene pairs in Escheric...

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Bibliographic Details
Main Authors: Alla Gagarinova, Geordie Stewart, Bahram Samanfar, Sadhna Phanse, Carl A. White, Hiroyuki Aoki, Viktor Deineko, Natalia Beloglazova, Alexander F. Yakunin, Ashkan Golshani, Eric D. Brown, Mohan Babu, Andrew Emili
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
E. coli
growth
protein synthesis
ribosome biogenesis
translational fidelity
double mutant
fitness
synthetic genetic array
genetic interaction
conditional rewiring
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312797

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http://www.sciencedirect.com/science/article/pii/S2211124716312797

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