Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena throu...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06769-y |
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doaj-daba42e8bc934c15ab731e4faf7ff42c |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Christoffer Clemmensen Sigrid Jall Maximilian Kleinert Carmelo Quarta Tim Gruber Josefine Reber Stephan Sachs Katrin Fischer Annette Feuchtinger Angelos Karlas Stephanie E. Simonds Gerald Grandl Daniela Loher Eva Sanchez-Quant Susanne Keipert Martin Jastroch Susanna M. Hofmann Emmani B. M. Nascimento Patrick Schrauwen Vasilis Ntziachristos Michael A. Cowley Brian Finan Timo D. Müller Matthias H. Tschöp |
| spellingShingle |
Christoffer Clemmensen Sigrid Jall Maximilian Kleinert Carmelo Quarta Tim Gruber Josefine Reber Stephan Sachs Katrin Fischer Annette Feuchtinger Angelos Karlas Stephanie E. Simonds Gerald Grandl Daniela Loher Eva Sanchez-Quant Susanne Keipert Martin Jastroch Susanna M. Hofmann Emmani B. M. Nascimento Patrick Schrauwen Vasilis Ntziachristos Michael A. Cowley Brian Finan Timo D. Müller Matthias H. Tschöp Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes Nature Communications |
| author_facet |
Christoffer Clemmensen Sigrid Jall Maximilian Kleinert Carmelo Quarta Tim Gruber Josefine Reber Stephan Sachs Katrin Fischer Annette Feuchtinger Angelos Karlas Stephanie E. Simonds Gerald Grandl Daniela Loher Eva Sanchez-Quant Susanne Keipert Martin Jastroch Susanna M. Hofmann Emmani B. M. Nascimento Patrick Schrauwen Vasilis Ntziachristos Michael A. Cowley Brian Finan Timo D. Müller Matthias H. Tschöp |
| author_sort |
Christoffer Clemmensen |
| title |
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes |
| title_short |
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes |
| title_full |
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes |
| title_fullStr |
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes |
| title_full_unstemmed |
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes |
| title_sort |
coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-10-01 |
| description |
Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena through small-molecule combination therapy, and show that this treatment improves metabolic health of obese mice. |
| url |
https://doi.org/10.1038/s41467-018-06769-y |
| work_keys_str_mv |
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| _version_ |
1721448439245438976 |
| spelling |
doaj-daba42e8bc934c15ab731e4faf7ff42c2021-05-11T10:16:54ZengNature Publishing GroupNature Communications2041-17232018-10-019111310.1038/s41467-018-06769-yCoordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetesChristoffer Clemmensen0Sigrid Jall1Maximilian Kleinert2Carmelo Quarta3Tim Gruber4Josefine Reber5Stephan Sachs6Katrin Fischer7Annette Feuchtinger8Angelos Karlas9Stephanie E. Simonds10Gerald Grandl11Daniela Loher12Eva Sanchez-Quant13Susanne Keipert14Martin Jastroch15Susanna M. Hofmann16Emmani B. M. Nascimento17Patrick Schrauwen18Vasilis Ntziachristos19Michael A. Cowley20Brian Finan21Timo D. Müller22Matthias H. Tschöp23Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute of Biological and Medical Imaging, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Research Unit Analytical Pathology, Helmholtz Zentrum MünchenInstitute of Biological and Medical Imaging, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)Department of Physiology, and Biomedicine Discovery Institute, Monash UniversityInstitute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute of Diabetes and Regeneration Research, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH)Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical CenterDepartment of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical CenterInstitute of Biological and Medical Imaging, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH)Department of Physiology, and Biomedicine Discovery Institute, Monash UniversityInstitute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen & German Center for Diabetes Research (DZD)Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena through small-molecule combination therapy, and show that this treatment improves metabolic health of obese mice.https://doi.org/10.1038/s41467-018-06769-y |