Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH

by Brian Finan, Sebastian D. Parlee, Bin Yang
Published 2021-04-01

Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety

by Rongjun He, Brian Finan, John P. Mayer, Richard D. DiMarchi
Published 2019-05-01

A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs

by Rongjun He, Stephanie A. Mowery, Joseph Chabenne, Brian Finan, John P. Mayer, Richard D. DiMarchi
Published 2021-08-01

Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice

by Sigrid Jall, Brian Finan, Gustav Collden, Katrin Fischer, Xinzhong Dong, Matthias H. Tschöp, Timo D. Müller, Christoffer Clemmensen
Published 2019-05-01

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

by Piotr A. Mroz, Brian Finan, Vasily Gelfanov, Bin Yang, Matthias H. Tschöp, Richard D. DiMarchi, Diego Perez-Tilve
Published 2019-02-01

G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.

by Anne Müller, Gunnar Kleinau, Carolin L Piechowski, Timo D Müller, Brian Finan, Juliane Pratzka, Annette Grüters, Heiko Krude, Matthias Tschöp, Heike Biebermann
Published 2013-01-01

Pharmacological antagonism of the incretin system protects against diet-induced obesity

by Berit Svendsen, Megan E. Capozzi, Jingjing Nui, Sarah A. Hannou, Brian Finan, Jacqueline Naylor, Peter Ravn, David A. D'Alessio, Jonathan E. Campbell
Published 2020-02-01

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice

by Sigrid Jall, Stephan Sachs, Christoffer Clemmensen, Brian Finan, Frauke Neff, Richard D. DiMarchi, Matthias H. Tschöp, Timo D. Müller, Susanna M. Hofmann
Published 2017-05-01

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

by Archita Agrawal, Sebastian Parlee, Diego Perez-Tilve, Pengyun Li, Jia Pan, Piotr A. Mroz, Ann Maria Kruse Hansen, Birgitte Andersen, Brian Finan, Alexei Kharitonenkov, Richard D. DiMarchi
Published 2018-07-01

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

by Aaron Novikoff, Shannon L. O'Brien, Miriam Bernecker, Gerald Grandl, Maximilian Kleinert, Patrick J. Knerr, Kerstin Stemmer, Martin Klingenspor, Anja Zeigerer, Richard DiMarchi, Matthias H. Tschöp, Brian Finan, Davide Calebiro, Timo D. Müller
Published 2021-07-01

Fibroblast activation protein (FAP) as a novel metabolic target

by Miguel Angel Sánchez-Garrido, Kirk M. Habegger, Christoffer Clemmensen, Cassie Holleman, Timo D. Müller, Diego Perez-Tilve, Pengyun Li, Archita S. Agrawal, Brian Finan, Daniel J. Drucker, Matthias H. Tschöp, Richard D. DiMarchi, Alexei Kharitonenkov
Published 2016-10-01

Glucagon receptor signaling regulates weight loss via central KLB receptor complexes

by Shelly R. Nason, Jessica Antipenko, Natalie Presedo, Stephen E. Cunningham, Tanya H. Pierre, Teayoun Kim, Jodi R. Paul, Cassie Holleman, Martin E. Young, Karen L. Gamble, Brian Finan, Richard DiMarchi, Chad S. Hunter, Alexei Kharitonenkov, Kirk M. Habegger
Published 2021-02-01

Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα

by Eugenia Morselli, Esther Fuente-Martin, Brian Finan, Min Kim, Aaron Frank, Cristina Garcia-Caceres, Carlos Rodriguez Navas, Ruth Gordillo, Michael Neinast, Sarada P. Kalainayakan, Dan L. Li, Yuanqing Gao, Chun-Xia Yi, Lisa Hahner, Biff F. Palmer, Matthias H. Tschöp, Deborah J. Clegg
Published 2014-10-01

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs

by Simone Renner, Andreas Blutke, Britta Dobenecker, Georg Dhom, Timo D. Müller, Brian Finan, Christoffer Clemmensen, Maren Bernau, Istvan Novak, Birgit Rathkolb, Steffanie Senf, Susanne Zöls, Mirjam Roth, Anna Götz, Susanna M. Hofmann, Martin Hrabĕ de Angelis, Rüdiger Wanke, Ellen Kienzle, Armin M. Scholz, Richard DiMarchi, Mathias Ritzmann, Matthias H. Tschöp, Eckhard Wolf
Published 2018-10-01

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

by Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D. Müller, Matthias H. Tschöp
Published 2018-10-01

Publisher Correction: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

by Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D. Müller, Matthias H. Tschöp
Published 2018-11-01

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

by Anders B. Klein, Trine S. Nicolaisen, Niels Ørtenblad, Kasper D. Gejl, Rasmus Jensen, Andreas M. Fritzen, Emil L. Larsen, Kristian Karstoft, Henrik E. Poulsen, Thomas Morville, Ronni E. Sahl, Jørn W. Helge, Jens Lund, Sarah Falk, Mark Lyngbæk, Helga Ellingsgaard, Bente K. Pedersen, Wei Lu, Brian Finan, Sebastian B. Jørgensen, Randy J. Seeley, Maximilian Kleinert, Bente Kiens, Erik A. Richter, Christoffer Clemmensen
Published 2021-02-01

Hypothalamic leptin action is mediated by histone deacetylase 5

by Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda, Kerstin Stemmer, Stephen C. Woods, Diego Perez-Tilve, Robert Schneider, Eric N. Olson, Matthias H. Tschöp, Paul T. Pfluger
Published 2016-02-01

The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

by Katrin Fischer, Anna Fenzl, Dianxin Liu, Kenneth A. Dyar, Maximilian Kleinert, Markus Brielmeier, Christoffer Clemmensen, Anna Fedl, Brian Finan, Andre Gessner, Martin Jastroch, Jianfeng Huang, Susanne Keipert, Martin Klingenspor, Jens C. Brüning, Manfred Kneilling, Florian C. Maier, Ahmed E. Othman, Bernd J. Pichler, Ines Pramme-Steinwachs, Stephan Sachs, Angelika Scheideler, Wolfgang M. Thaiss, Henriette Uhlenhaut, Siegfried Ussar, Stephen C. Woods, Julia Zorn, Kerstin Stemmer, Sheila Collins, Maria Diaz-Meco, Jorge Moscat, Matthias H. Tschöp, Timo D. Müller
Published 2020-05-01