Genomic analysis of ERVWE2 locus in patients with Multiple sclerosis: absence of genetic association but potential role of Human Endogenous retrovirus type W elements in molecular mimicry with myelin antigen.

Genomic analysis of ERVWE2 locus in patients with Multiple sclerosis: absence of genetic association but potential role of Human Endogenous retrovirus type W elements in molecular mimicry with myelin antigen.

Human endogenous retroviruses (HERVs) arise from ancient infections of the host germline cells by exogenous retroviruses, constituting 8% of the human genome. Elevated level of envelope transcripts from HERVs-W has been detected in CSF, plasma and brain tissues from patients with Multiple Sclerosis...

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Bibliographic Details
Main Authors: Guilherme S Olival, Thiago Santiago Faria, Luiz Henrique S Nali, Augusto Cesar Penalva de Oliveira, Jorge SR Casseb, Jose Ernesto eVidal, Vitor eCavenaghi, Charles eTilbery, Lenira eMoraes, Maria Cristina eFink, Laura eSumita, Hervé ePerron, Camila Malta Romano
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Microbiology
Subjects:
Endogenous Retroviruses
Multiple Sclerosis
Genetic association
Immunopathogenesis
MOG
ERVWE2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00172/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00172/full

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