Adhesins of Leptospira interrogans mediate the interaction to fibrinogen and inhibit fibrin clot formation in vitro.

Adhesins of Leptospira interrogans mediate the interaction to fibrinogen and inhibit fibrin clot formation in vitro.

We report in this work that Leptospira strains, virulent L. interrogans serovar Copenhageni, attenuated L. interrogans serovar Copenhageni and saprophytic L. biflexa serovar Patoc are capable of binding fibrinogen (Fg). The interaction of leptospires with Fg inhibits thrombin- induced fibrin clot fo...

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Bibliographic Details
Main Authors: Rosane Oliveira, Renan F Domingos, Gabriela H Siqueira, Luis G Fernandes, Natalie M Souza, Monica L Vieira, Zenaide M de Morais, Silvio A Vasconcellos, Ana L T O Nascimento
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3757074?pdf=render

Internet

http://europepmc.org/articles/PMC3757074?pdf=render

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