Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data
Lineage tracing studies combining CRISPR-Cas9 editing and scRNA-seq face several challenges and cannot integrate lineages from multiple individuals. Here the authors show that integration of mutation and expression leads to accurate lineage tree inference and enables the learning of a species-invari...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16821-5 |