The Potential Safe Antifibrotic Effect of Stem Cell Conditioned Medium and Nilotinib Combined Therapy by Selective Elimination of Rat Activated HSCs

Hepatic fibrosis is a progressive disease with serious clinical complications that arise from abnormal propagation and activation of multiple inflammatory pathways. Nilotinib is an oral tyrosine kinase inhibitor with antifibrotic activity. Mesenchymal stem cells (MSCs) are blank cells and can differ...

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Bibliographic Details
Main Authors: Ahmed Nabil, Koichiro Uto, Faten Zahran, Reham Soliman, Ayman A. Hassan, Mohamed M. Elshemy, Islam S. Ali, Mitsuhiro Ebara, Gamal Shiha
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2021/6678913