BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

Preventing phosphorylation of BAD (3SA) in mouse models and human cells inhibits mammary gland development, acting by disrupting 4E-BP1- mediated translation and affecting focal adhesion/protrusion stability, cell migration and ductal tubulogenesis.

Bibliographic Details
Main Authors: John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill, Ing Swie Goping
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23269-8

Internet

https://doi.org/10.1038/s41467-021-23269-8

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