Structural Requirements for the Antifungal Activities of Natural Drimane Sesquiterpenes and Analogues, Supported by Conformational and Electronic Studies

Structural Requirements for the Antifungal Activities of Natural Drimane Sesquiterpenes and Analogues, Supported by Conformational and Electronic Studies

Seventeen drimanes including polygodial (1), isopolygodial (2), drimenol (3) and confertifolin (4) obtained from natural sources and the semi-synthetic derivatives 5–17 obtained from 1–3, were evaluated in vitro for antifungal properties against a unique panel of fungi with standardized procedures b...

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Bibliographic Details
Main Authors: Susana A. Zacchino, Mauricio Cuellar Fritis, Ricardo D. Enriz, Francisco Garibotto, Marcos Derita, Iván Montenegro
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Molecules
Subjects:
antifungal agents
drimanes
structure-activity relationships
stereo-electronic studies
Online Access:http://www.mdpi.com/1420-3049/18/2/2029

Internet

http://www.mdpi.com/1420-3049/18/2/2029

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