A stochastic inference of de novo CNV detection and association test in multiplex schizophrenia families

A stochastic inference of de novo CNV detection and association test in multiplex schizophrenia families

The copy number variation (CNV) is a type of genetic variation in the genome. It is measured based on signal intensity measures and can be assessed repeatedly to reduce the uncertainty in PCR-based typing. Studies have shown that CNVs may lead to phenotypic variation and modification of disease expr...

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Bibliographic Details
Main Authors: Shi-Heng eWang, Wei J. Chen, Yu-Chin eTsai, Yung-Hsiang eHuang, Hai-Gwo eHwu, Chuhsing Kate eHsiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Genetics
Subjects:
Bayesian model
Mendelian inconsistency
CNV association test
de novo CNV detection
schizophrenia multiplex family
random mutation parameter
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00185/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00185/full

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