Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/β-Catenin/ABCG2 Axis

Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/β-Catenin/ABCG2 Axis

Accumulating evidence suggests that the root of drug chemoresistance in breast cancer is tightly associated with subpopulations of cancer stem cells (CSCs), whose activation is largely dependent on taxol-promoting autophagy. Our pilot study identified GRP78 as a specific marker for chemoresistance p...

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Bibliographic Details
Main Authors: Mianmian Liao, Caiwei Wang, Bowen Yang, Danping Huang, Yifeng Zheng, Shengqi Wang, Xuan Wang, Juping Zhang, Chunbian Tang, Zheng Xu, Yu He, Ruolin Huang, Fengxue Zhang, Zhiyu Wang, Neng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
breast cancer chemosensitivity
cancer stem cells
autophagy
Ai Du Qing formula
GRP78/β-catenin/ABCG2 axis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.659297/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.659297/full

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