Compensatory interactions between Sir3p and the nucleosomal LRS surface imply their direct interaction.
The previously identified LRS (Loss of rDNA Silencing) domain of the nucleosome is critically important for silencing at both ribosomal DNA and telomeres. To understand the function of the LRS surface in silencing, we performed an EMS mutagenesis screen to identify suppressors of the H3 A75V LRS all...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-12-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2587916?pdf=render |