Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients

Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients

Mutations in hepatitis B virus (HBV) surface promoter II (SPII) have not been well studied in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients. We aimed to investigate SPII mutations in such patients and their biological and clinical impacts. Direct sequencing was used to de...

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Bibliographic Details
Main Authors: Ran Hao, Kuanhui Xiang, Yan Shi, Dong Zhao, Huifang Tian, Baohong Xu, Yufang Zhu, Huan Dong, Hai Ding, Hui Zhuang, Jie Hu, Tong Li
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Viruses
Subjects:
hepatitis B virus
surface promoter
HBsAg
mutation
HBeAg-positive
C genotype
Online Access:http://www.mdpi.com/1999-4915/11/1/78

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http://www.mdpi.com/1999-4915/11/1/78

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