Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation

Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation

Abstract Patients with late‐stage Kellgren‐Lawrence knee osteoarthritis received a single intra‐articular injection of 1, 10, or 50 million bone marrow mesenchymal stromal cells (BM‐MSCs) in a phase I/IIa trial to assess safety and efficacy using a broad toolset of analytical methods. Besides safety...

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Bibliographic Details
Main Authors: Jaskarndip Chahal, Alejandro Gómez‐Aristizábal, Konstantin Shestopaloff, Shashank Bhatt, Amélie Chaboureau, Antonietta Fazio, Jolene Chisholm, Amanda Weston, Julia Chiovitti, Armand Keating, Mohit Kapoor, Darrell J. Ogilvie‐Harris, Khalid A. Syed, Rajiv Gandhi, Nizar N. Mahomed, Kenneth W. Marshall, Marshall S. Sussman, Ali M. Naraghi, Sowmya Viswanathan
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Stem Cells Translational Medicine
Subjects:
Arthritis
Mesenchymal stem cells
Monocyte
Cellular therapy
Clinical trials
Selectable marker
Online Access:https://doi.org/10.1002/sctm.18-0183

Internet

https://doi.org/10.1002/sctm.18-0183

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