Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming

Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming

Abstract Protein SUMOylation is a dynamic post-translational modification shown to be involved in a diverse set of physiologic processes throughout the cell. SUMOylation has also been shown to play a role in the pathobiology of myriad cancers, one of which is glioblastoma multiforme (GBM). As such,...

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Bibliographic Details
Main Authors: Joshua D. Bernstock, Daniel Ye, Florian A. Gessler, Yang-ja Lee, Luca Peruzzotti-Jametti, Peter Baumgarten, Kory R. Johnson, Dragan Maric, Wei Yang, Donat Kögel, Stefano Pluchino, John M. Hallenbeck
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07631-9

Internet

https://doi.org/10.1038/s41598-017-07631-9

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