Vanadium pentoxide increased PTEN and decreased SHP1 expression in NK-92MI cells, affecting PI3K-AKT-mTOR and Ras-MAPK pathways

Vanadium pentoxide increased PTEN and decreased SHP1 expression in NK-92MI cells, affecting PI3K-AKT-mTOR and Ras-MAPK pathways

Vanadium is an air pollutant that imparts immunosuppressive effects on NK cell immune responses, in part, by dysregulating interleukin (IL)-2/IL-2R-mediated JAK signaling pathways and inducing apoptosis. The aim of the present study was to evaluate effects of vanadium pentoxide (V2O5) on other IL-2...

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Bibliographic Details
Main Authors: Francisco Gallardo-Vera, Miguel Tapia-Rodriguez, Daniel Diaz, Teresa Fortoul van der Goes, Luis F. Montaño, Erika P. Rendón-Huerta
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Immunotoxicology
Subjects:
Vanadium pentoxide
IL-2
NK cells
IL-2R
signaling pathway
PTEN
SHP1
Online Access:http://dx.doi.org/10.1080/1547691X.2017.1404662

Internet

http://dx.doi.org/10.1080/1547691X.2017.1404662

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