A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity.

A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity.

Centromere-associated protein E (CENP-E) regulates both chromosome congression and the spindle assembly checkpoint (SAC) during mitosis. The loss of CENP-E function causes chromosome misalignment, leading to SAC activation and apoptosis during prolonged mitotic arrest. Here, we describe the biologic...

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Bibliographic Details
Main Authors: Akihiro Ohashi, Momoko Ohori, Kenichi Iwai, Tadahiro Nambu, Maki Miyamoto, Tomohiro Kawamoto, Masanori Okaniwa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4674098?pdf=render

Internet

http://europepmc.org/articles/PMC4674098?pdf=render

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