Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung

Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung

Abstract Background Tbx2 encodes a transcriptional repressor implicated in the development of numerous organs in mouse. During lung development TBX2 maintains the proliferation of mesenchymal progenitors, and hence, epithelial proliferation and branching morphogenesis. The pro-proliferative function...

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Bibliographic Details
Main Authors: Timo H. Lüdtke, Irina Wojahn, Marc-Jens Kleppa, Jasper Schierstaedt, Vincent M. Christoffels, Patrick Künzler, Andreas Kispert
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Respiratory Research
Subjects:
Tbx2
Pulmonary mesenchyme
Lung development
NuRD
HDAC
CBX3
Online Access:https://doi.org/10.1186/s12931-021-01679-y

Internet

https://doi.org/10.1186/s12931-021-01679-y

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