Mouse renal 4T1 cell engraftment as a model to study the influence of hypoxia in breast cancer progression

Mouse renal 4T1 cell engraftment as a model to study the influence of hypoxia in breast cancer progression

PURPOSE: To develop a mouse model to study the influence of hypoxia in breast cancer progression and metastasis. METHODS: The 4T1 cell line was used to engraft the kidneys of female BALB/c mice. Placing an aneurysm clip on the kidney hilum, hypoxia can be directed to tumor site. Histological evaluat...

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Bibliographic Details
Main Authors: Heriton Marcelo Ribeiro Antonio, Larissa Raquel Mouro Mandarano, Alan Augusto Coelho, Marcelo Guimarães Tiezzi, Jurandyr Moreira de Andrade, Daniel Guimarães Tiezzi
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2013-02-01
Series:Acta Cirurgica Brasileira
Subjects:
Models, Animal
Breast Neoplasms
Anoxia
Kidney
Mice
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000200010

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000200010

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