The autophagic defect in Niemann–Pick disease type C neurons differs from somatic cells and reduces neuronal viability
Niemann–Pick disease type C (NPC) is a fatal, progressive neurovisceral disorder. Several studies report that the autophagic flux is disturbed in NPC1-deficient (NPC1−/−) cells. Since it has been suggested that the autophagic defect may contribute to the neurodegeneration, we used cell cultures of N...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-04-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996114000059 |