Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells.

Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells.

Heat shock protein 90 (Hsp90) has been identified in the extracellular space and has been shown to chaperone a finite number of extracellular proteins involved in cell migration and invasion. We used chemical cross-linking and immunoprecipitation followed by tandem mass spectrometry (MS/MS) to isola...

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Bibliographic Details
Main Authors: Morgan C Hunter, Kyle L O'Hagan, Amy Kenyon, Karim C H Dhanani, Earl Prinsloo, Adrienne L Edkins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24466266/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24466266/?tool=EBI

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