NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus

NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus

Summary: FBXL2 targets IP3R3 for ubiquitin-mediated degradation to limit Ca2+ flux to mitochondria and, consequently, apoptosis. Efficient replication of hepatitis C virus (HCV) requires geranylgeranylation of FBXL2. Here, we show that the viral protein NS5A forms a trimeric complex with IP3R3 and F...

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Bibliographic Details
Main Authors: Shafi Kuchay, Mohsan Saeed, Carlotta Giorgi, Jie Li, Hans-Heinrich Hoffmann, Paolo Pinton, Charles M. Rice, Michele Pagano
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718315596

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http://www.sciencedirect.com/science/article/pii/S2211124718315596

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