Conidial Melanin of the Human-Pathogenic Fungus Aspergillus fumigatus Disrupts Cell Autonomous Defenses in Amoebae

Conidial Melanin of the Human-Pathogenic Fungus Aspergillus fumigatus Disrupts Cell Autonomous Defenses in Amoebae

Infections with Aspergillus fumigatus are usually acquired by an inhalation of spores from environmental sources. How spores of a saprophytic fungus have acquired abilities to withstand and escape the phagocytic attacks of innate immune cells is not understood. The fungal surface pigment dihydroxyna...

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Bibliographic Details
Main Authors: Iuliia Ferling, Joe Dan Dunn, Alexander Ferling, Thierry Soldati, Falk Hillmann
Format: Article
Language:English
Published: American Society for Microbiology 2020-05-01
Series:mBio
Subjects:
aspergillus fumigatus
dictyostelium discoideum
protostelium aurantium
dhn-melanin
phagocytosis
phagosome maturation
acidification
v-atpase
ros
nadph oxidase
membrane damage
membrane repair
escrt machinery
fungi
amoeba
pathogens
Online Access:https://doi.org/10.1128/mBio.00862-20

Internet

https://doi.org/10.1128/mBio.00862-20

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