Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers

Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers

Gastrointestinal (GI) malignancies are a major global health burden, with high mortality rates. The identification of novel therapeutic strategies is crucial to improve treatment and survival of patients. The poly (ADP-ribose) polymerase (PARP) enzymes involved in the DNA damage response (DDR) play...

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Bibliographic Details
Main Authors: Abdullah Alhusaini, Aoife Cannon, Stephen G. Maher, John V. Reynolds, Niamh Lynam-Lennon
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
PARP
PARP inhibitors
gastrointestinal cancers
DNA damage response
chemoradiotherapy resistance
Online Access:https://www.mdpi.com/2227-9059/9/8/1024

Internet

https://www.mdpi.com/2227-9059/9/8/1024

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