Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

mTORC1 regulates cellular growth from the lysosome, but how changes in the organisation of the lysosomal system affect mTORC1 signalling is poorly understood. Here the authors show that amino acid-dependent Rap1-mediated changes in lysosomal abundance determine overall signalling output of mTORC1.

Bibliographic Details
Main Authors: Anders P. Mutvei, Michal J. Nagiec, Jens C. Hamann, Sang Gyun Kim, C. Theresa Vincent, John Blenis
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15156-5

Internet

https://doi.org/10.1038/s41467-020-15156-5

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